Interleukin 15, Recombinant, Human (Interleukin-15, IL15, IL-15, MGC9721)

Source:\nRecombinant corresponding to 114aa of human Interleukin-15 expressed in E.coli is a single, non-glycosylated polypeptide chain.\n\nMolecular Weight:\n~12.8kD\n\nDimers and Aggregates:\n(same/less than)1% (SDS-PAGE)\n\nProtein Content:\nProtein quantitation was carried out by two independent methods: 1.UV spectroscopy at 280nm using the absorbency value of 0.55 as the extinctioncoefficient for a 0.1% (1mg/ml) solution. This value is calculated by the PC GENE computer analysis program of protein sequences (IntelliGenetics). 2.Analysis by RP-HPLC, using a calibrated solution of IL-15 as a Reference Standard.\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile ddH2O, HSA or BSA. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

I8437-01H

Size

2ug

Form

Supplied as a lyophilized powder. No preservative added. Reconstitute with sterile dH2O, 0.1% HSA or BSA to (same/more than)0.1mg/ml.

Purity

~98% (RP-HPLC, Anion-exchange FPLC, SDS-PAGE) Endotoxin: (same/less than)0.1ng/ug (IEU/ug)

References

1. Targeting interleukin-15 in patients with rheumatoid arthritis: a proof-of-concept study. Arthritis Rheum 2005 Sep;52(9):2686-92. 2. Targeting the interleukin-15 system in rheumatoid arthritis. Arthritis Rheum 2005 Sep;52(9):2585-8. 3. Serum interleukin-15 concentration in patients with essential hypertension. Am J Hypertens 2005 Aug;18(8):1019-25. 4. Interleukin-15 in hypertension: further insights into inflammation and vascular disease. Am J Hypertens 2005 Aug;18(8):1017-8. 5. Interleukin-15 decreases proteolysis in skeletal muscle: a direct effect. Int J Mol Med 2005 Sep;16(3):471-6. 6. Inhibition of lymphocyte apoptosis by pancreatic stellate cells: impact of interleukin-15. Am J Physiol Gastrointest Liver Physiol 2005 Nov;289(5):G842-51.