Interleukin 16, Recombinant, Mouse (IL-16)

Recombinant Murine IL-16 is a proinflammatory cytokine inducing immunomodulatory effects of CD41 lymphocytes, monocytes, and eosinophils via CD4. Comparative analysis of murine and human IL-16 show a high degree of amino acid similarity. The highest similarity (82.1%) was found in the C-terminal region. Chemotaxis experiments with IL-16 of murine and human origin, using murine splenocytes or human T lymphocytes as targets, showed cross-species motility. There is a high degree of structural and functional similarity between human and murine IL-16. Murine IL-16 is comprised of 127 amino acids, with a molecular weight of 13.2kD.\n\nBiological Activity: Recombinant mouse IL-16 has full biologicial activity compared to a standard. The activity, determined by dose-dependent chemoattraction of lprimary human T cells, is detectable at ~5ng/ml\n\nAA Sequence:\nMHDLNSSTDS AASASAASDI SVESKEATVC TVTLEKTSAG LGFSLEGGKG SLHGDKPLTI NRIFKGDRTG EMVQPGDEIL QLAGTAVQGL TRFEAWNVIK ALPDGPVTIV IRRTSLQCKQ TTASADS\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile ddH2O, aliquot and store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

I8437-07B

Size

2ug

Form

Supplied as a lyophilized powder. Reconstitute with sterile ddH2O to a concentration of 0.1mg/ml. For long term storage add 0.1% BSA or HSA. Further dilution can be made in other aqueous solutions.\n

Purity

(same/more than) 95% (HPLC, reducing and non-reducing SDS-PAGE, UV). Endotoxin: (same/less than)0.1EU/ug.