Interleukin 18 (IL-18, IFN-gamma inducing factor, IGIF) (Biotin)

Interleukin-18 is a member of the interleukin-1 family of cytokines with pro-inflammatory and tumor-suppressive properties. Its ability to potently enhance the production of interferon-gamma indicates in particular the crucial function of interleukin-18 as an immunomodulatory molecule. In fact, high levels of interleukin-18 are detected in human diseases associated with immunoactivation including viral or bacterial infections and chronic inflammation. Animal models suggest suppression of interleukin-18 bioactivity as a novel therapeutic concept specifically for the treatment of chronic inflammatory diseases such as rheumatoid arthritis, Crohn's disease, and psoriasis. It is the only cytokine with a unique capacity to induce T helper 1 or T helper 2 polarization, depending on the immunologic context.\n\nApplications:\nSuitable for use in ELISA. Other applications have not been tested. \n\nRecommended Dilutions:\nOptimal working dilutions to be determined by researcher.\n\nRecommended Pair:\nCapture: I8439-95E\nDetection: I8439-95C\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

I8439-95C

Size

250ug

Applications

ELISA

Hosts

Mouse

Reactivities

Prc

Conjugates

Biotin

Form

Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide. Labeled with Biotin.

P Type

Mab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG1

References

1. Muneta, Y. et al., (2000) Detection of porcine interleukin-18 by sandwich ELISA and immunohistochemical staining using its monoclonal antibodies. J. Interferon Cytokine Res. 20: 331 - 336.

Additional Info

Recognizes natural and recombinant porcine IL-18. Does not recognize porcine IL-1beta, IL-8, IL-12 or IFNgamma, nor does it recognize human or mouse IL-18.