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Interleukin 23, Recombinant, Human (IL-23)

Cat no: I8443-40D

Interleukin 23, Recombinant, Human (IL-23)

IL-23 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines (1). It exists as a heterodimer composed of the IL-12 p40 subunit and a novel p19 subunit (2). IL-23 is secreted by activated dendritic cells, macrophages, and monocytes.\n\nProduced in HEK 293 cells. Mature human IL-23 (interleukin-23) p40 peptide (aa23-328) is fused at the C-terminus to a 18aa linker peptide, GSTSGSGKPGSGEGSTKG and to the mature p19 peptide (aa20-189) and fused at the N-terminus to a FLAG(R)-tag.\n\nBiological Activity: Induction of IL-17 secretion by mouse splenocytes.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing.. Store at -20 degrees C. Aliquots are stable for at least 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

I8443-40D

Size

10ug

Form

Supplied as a sterile-filtered liquid in PBS.

Purity

(same/more than)90% (SDS-PAGE)Endotoxin: (same/less than) 0.1EU/ug (LAL)

References

1. Hunter, C.A., (2005),

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