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Interleukin 33, Human (IL-33) BioAssay(TM) ELISA Kit

Cat no: I7663-97K

Interleukin 33, Human (IL-33) BioAssay(TM) ELISA Kit

Interleukin-1 (IL-1) family members, such as IL-19/: and IL-18, play important roles in host defense, immune regulation, neuronal injury and inflammation (1, 2). Recently, a new member of this family, IL-33, also named Nuclear Factor, from High Endothelial Venules (NF-HEV) (3), has been reported. It mediates its biological effects via IL-1 receptor ST2 (4), an orphan receptor of the IL-1 receptor family (5), and activates NF-kB and MAPK pathways. IL-33 is synthesized in response to cytokines such as IL-1: and plays an important role in TH2-associated immunology. IL-33 expression drives production of TH2-associated cytokines from in vitro polarized TH2 cells and induces the expression of IL-4, IL-5, and IL-13 in vivo. Overexpression of IL-33 in mice leads to severe pathological changes in mucosal organs. Structurally, IL-33 is closest to IL-18, rather than IL-1:. The human IL-33 is expressed with a prodomain (aa1-111) that is cleaved by caspase-1 to produce a 18kD protein (112-270) (6).\n\nSample Type:\nSerum/Plasma\n\nKit Components: (enough for 2x96-well plates)\nCoating Antibody, 1x1vial, Affinity-purified Chicken anti-Human IL-33\nCalibrator, 1x1vial, Pure Human IL-33 protein\nHRP Detection Antibody, 1x1vial, Affinity-purified Chicken anti-Human IL-33

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SPECIFICATIONS

Catalog Number

I7663-97K

Size

2Plates

Alternative Names

Interleukin-33, C9orf26, DKFZp586H0523, DVS27, Interleukin-1 Family Member 11, IL1F11, IL-1F11, Nuclear Factor from High Endothelial Venules, NFEHEV, NFHEV, NF-HEV, RP11-575C20.2

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