Home  >  Products  >  Interleukin-4, Recombinant, Human (IL-4, B-cell Stimulatory Factor 1, BSF-1, Binetrakin, Lymphocyte Stimulatory Factor 1, Pitrakinra, IL4, MGC79402)

Interleukin-4, Recombinant, Human (IL-4, B-cell Stimulatory Factor 1, BSF-1, Binetrakin, Lymphocyte Stimulatory Factor 1, Pitrakinra, IL4, MGC79402)

Cat no: 149629


Supplier: United States Biological
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IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant human IL-4 is a 14.9kD globular protein containing 129aa. Source: Recombinant protein corresponding to human IL-4, expressed in E.coli. Biological Activity: Determined by the dose-dependent stimulation of human TF-1 cells. The ED50 was found to be 0.2ng/ml. Specific Activity: 5x10e6units/mg Endotoxin: <0.1ng/ug (1EU/ug) AA Sequence: MHKCDITLQE IIKTLNSLTE QKTLCTELTV TDIFAASKNT TEKETFCRAA TVLRQFYSHH EKDTRCLGAT AQQFHRHKQL IRFLKRLDRN LWGLAGLNSC PVKEANQSTL ENFLERLKTI MREKYSKCSS Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: 149629
Size: 2ug
Form: Supplied as a lyophilized powder.
Purity: ~98% (SDS-PAGE and HPLC)

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