IL-5 is a hematopoietic growth factor that stimulates the proliferation and activation of eosinophils. Produced by mast cells, T cells, and eosinophils, IL-5 plays an important role in inducing cell-mediated immunity against parasitic infections and certain tumors. Elevated levels of IL-5 lead to Eosinophilia, which may result in the induction of asthma and other allergic diseases. Human and murine IL-5 is cross-species reactive. Recombinant mouse IL-5 is a 26.2kD disulfide-linked homodimeric protein containing two 113aa chains.
Source:
Recombinant protein corresponding to mouse IL-5, expressed in E.coli.
Biological Activity:
Determined by the dose-dependent stimulation of the proliferation of human TF-1 cells. The ED50 was found to be <2ng/ml.
Specific Activity:
>5x10e5units/mg.
Endotoxin:
<0.1ng/ug (1EU/ug)
AA Sequence:
MEIPMSTVVK ETLTQLSAHR ALLTSNETMR LPVPTHKNHQ LCIGEIFQGL DILKNQTVRG GTVEMLFQNL SLIKKYIDRQ KEKCGEERRR TRQFLDYLQE FLGVMSTEWA MEG
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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