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Interleukin 7 Receptor alpha, Mouse IgG2a Fc Fusion Protein (Interleukin-7 Receptor Subunit alpha, IL-7 Receptor Subunit alpha, IL-7R Subunit alpha, IL-7R-alpha, IL7RA, IL-7RA, IL7R, CD127, CDw127, ILRA)

Cat no: I8429-27N

Interleukin 7 Receptor alpha, Mouse IgG2a Fc Fusion Protein (Interleukin-7 Receptor Subunit alpha, IL-7 Receptor Subunit alpha, IL-7R Subunit alpha, IL-7R-alpha, IL7RA, IL-7RA, IL7R, CD127, CDw127, ILRA)

CD127 (IL-7Ra) is the specific receptor component for the cytokine Interleukin -7 (IL-7). It is found on a wide variety of hematopoietic cell types including B cell precursors, and the majority of T cells. Its expression levels are decreased on T cells following activation. CD127 can dimerize with CD132 (IL-2R delta) to form a high affinity IL-7 receptor (1). CD127 engagement is necessary for T cell development in humans (2).\n\nMolecular Structure: A soluble molecule consisting of murine CD8 alpha signal peptide residual amino acids and linker, the mature extracellular domain of human CD127 (IL-7Ra) and murine IgG2a Fc + hinge regions (464 aa total). The molecule is dimeric with a predicted monomeric non glycosylated molecular weight of 52.8kD.\n\nApplications:\nSuitable for use in ELISA and Flow Cytometry. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

I8429-27N

Size

25ug

Applications

ELISA, FC

Form

Supplied as liquid in 50mM sodium phosphate pH 7.5, 100mM potassium chloride, 150mM sodium chloride, 0.5mg/ml gentamicin sulfate.

Purity

Purified by Protein A affinity chromatography.

References

1. Noguchi, M. et al., 1993, Science 262:1877, 2. Pribyl, J.A. and T.W. LeBien, 1996, Proc. Natl. Acad. Sci. 93:10348, 3. Goodwin RG, Friend D, Ziegler SF, et al. Cell. 1990; 60:941.

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