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Involucrin (P568) Peptide

Cat no: BS1189P

Involucrin (P568) Peptide

Involucrin is a precursor protein of the keratinocyte cornified envelope, which is formed beneath the inner surface of the cell membrane during terminal differentiation. Involucrin first appears in the cell cytosol but ultimately becomes cross-linked to membrane proteins by transglutaminase. During keratinocyte terminal differentiation glutamine residues of involucrin become covalently cross-linked to other envelope precursors via covalent E-(gamma -glutamyl) lysine bonds. Moreover, its large size allows involucrin to cross-link molecules that are separated by substantial distances in the cornified envelope. These properties allow a single involucrin molecule to form multiple cross-links, in multiple spatial planes, with other envelope precursors. Involucrin is specifically expressed in Chinese hamster ovarian cells (fibroblasts), PtK2 rat kangaroo kidney cells (simple epithelial) and rat epidermal keratinocytes (stratifying squamous epithelial).

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SPECIFICATIONS

Catalog Number

BS1189P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide Involucrin (P568). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

P07476

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS1189 Involucrin (P568) pAb.

Alternative Names

IVL

SUPPLIER INFO

Bioworld Technology, Inc.

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