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Ionomycin, Calcium Salt

Cat no: I8447-50

Ionomycin, Calcium Salt

Antibiotic that acts as a potent and selective calcium ionophore; more effective than A23187. Ionomycin binds Ca2+ in the 7.0-9.5pH range with the resulting complex exhibiting intense UV absorption.\n\nSolubility:\nAs Reported \n\nMelting Point:\nAs Reported \n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

I8447-50

Size

5mg

Form

As Reported

Purity

~99%

References

1. Liu, C. and Hermann T.E. \"Characterization of ionomycin as a calcium ionophore.\" J. Biol. Chem. 253:5892-5894 (1978). 2. Kauffman, R.F., et al. \"Cation transport and specificity of ionomycin. Comparison with ionophore A23187 in rat liver mitochondria.\" J. Biol. Chem. 255:2735-2739 (1980). 3. Takei, N. and Endo, Y. \"Ca2+ ionophore-induced apoptosis on cultured embryonic rat cortical neurons.\" Brain Res. 652:65-70 (1994). 4. Aagaard-Tillery, K.M., et al. \"Differential activation of a calcium-dependent endonuclease in human B lymphocytes. Role in ionomycin-induced apoptosis.\" J. Immunol. 155:3297-3307 (1995).

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