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IRAK1 (T381) Peptide

IRAK1 (T381) Peptide

Cat no: BS1541P

Supplier: Bioworld Technology, Inc.
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Three structurally related ligands for IL-1Rs have been described. These include two agonists, IL-1alpha and IL-1beta, and a specific receptor antagonist, IL-1Ralpha. Two distinct receptors designated IL-1RI and IL-1RII have been identified, each of which belong to the Ig superfamily. The preponderance of evidence suggests IL-1RI to be the functional IL-1 receptor. Binding of IL-1 to its cognate receptor results in the activation of the NFkB signaling pathway. The IL-1-dependent kinase termed IRAK (for IL-1 receptor-associated kinase) co-immunoprecipitates with activated IL-1RI and has been implicated as an upstream mediator of NFkB activation. Additional support for this assertion comes from the fact that a related Drosophila protein, Pelle, is a known upstream activator of Dorsal, the Drosophila homolog of NFkB.
Catalogue number: BS1541P
Applications: Block/Neutralize/Inhibit
Swiss prot: P51617
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide IRAK1 (T381). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: Interleukin-1 receptor-associated kinase 1; IRAK-1; IRAK1; IRAK
Additional info: This peptide can be used with studies using BS1541 IRAK1 (T381) pAb.

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