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Irisin:Fc, Recombinant, Human (Fibronectin Type III Domain-containing Protein 5, Fibronectin Type III Repeat-containing Protein 2, FNDC5)

Irisin:Fc, Recombinant, Human (Fibronectin Type III Domain-containing Protein 5, Fibronectin Type III Repeat-containing Protein 2, FNDC5)

Cat no: 044962

Supplier: United States Biological
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Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure. AA Sequence: aa16-127 of human Irisin fused at the C-terminus to the Fc portion of human IgG1. Species Homology: aa16-127 of human Irisin corresponds to aa29-140 of mouse Irisin. Irisin has 100% identity betwen mouse, rat, monkey and human. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: 044962
Size: 10ug
Form: Supplied as a lyophilized powder from PBS. Reconstitute with 100ul dH2O. Further dilutions can be made in PBS, >0.1% BSA.
Purity: ~95% (SDS-PAGE) Endotoxin: (same/less than)0.1EU/ug (LAL)
Alternative names: Fibronectin Type III Domain-containing Protein 5, Fibronectin Type III Repeat-containing Protein 2, FNDC5

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