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ISG15 pAb

ISG15 pAb

Cat no: BS6220


Supplier: Bioworld Technology, Inc.
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Ubiquitin-like protein that is conjugated to intracellular target proteins after IFN-alpha or IFN-beta stimulation. Its enzymatic pathway is partially distinct from that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes. ISG15 conjugation pathway uses a dedicated E1 enzyme, but seems to converge with the Ub conjugation pathway at the level of a specific E2 enzyme. Targets include STAT1, SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, EIF2AK2/PKR, MX1/MxA, and RIG-1. Deconjugated by USP18/UBP43. Shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. May serve as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments. May also be involved in autocrine, paracrine and endocrine mechanisms, as in cell-to-cell signaling, possibly partly by inducing IFN-gamma secretion by monocytes and macrophages. Seems to display antiviral activity during viral infections.
Catalogue number: BS6220
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: P05161
Dilutions: WB: 1:500~1:2000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Recombinant full length Human ISG15.
Species: ISG15 pAb detects endogenous levels of ISG15 protein.
Molecular weight: ~ 18 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: G1P2; hUCRP; IFI 15; IFI15; Interferon alpha inducible protein; Interferon stimulated protein 15 a; Interferon; alpha-inducible protein (clone IFI-15K); Interferon-induced 15 a protein; Interferon-induced 17 a protein; Interferon-induced 17- a/15- a protein; IP17; ISG 15; ISG15; ISG15 ubiquitin like modifier; ISG15; Ubiquitin cross-reactive protein; Ubiquitin-like protein ISG15; UCRP;
Additional info: For research use only, not for use in diagnostic procedure.

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