ITGAE (HML-1 antigen, Integrin alpha-IEL, Mucosal lymphocyte 1 antigen, CD103)

ITGAE(INTEGRIN, ALPHA-E), also known as CD103, is an integrin protein that in human is encoded by the ITGAE gene. The ITGAE gene is mapped to chromosome 17p13 by inclusion within a BAC contig. ITGAE is expressed widely on intraepithelial lymphocyte (IEL) T cells (both alphabeta T cells and gammad T cells) and on some peripheral regulatory T cells (Tregs) which is important for decreasing the immune response and appears to play a crucial role in the prevention of autoimmune diseases. ITGAE shares overall homology with other alpha integrins but has a unique 55-amino acid 'extra' region located just N-terminal to the I domain that contains 18 consecutive charged residues and a proteolytic cleavage site.\n\nUniProt Number:\nP38570\n\nGene ID:\nITGAE\n\nApplications:\nSuitable for use in Western Blot and Immunohistochemistry (Paraffin).\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Handling:\nStore at -20?C for one year. After reconstitution, store at 4?C for one month. Can also be aliquoted and stored frozen at -20?C for long term.\nAvoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

144788

Size

100ug

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a lyophilized powder. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1.Cerf-Bensussan, N., Jarry, A., Brousse, N., Lisowska-Grospierre, B., Guy-Grand, D., Griscelli, C. A monoclonal antibody (HML-1) defining a novel membrane molecular present on human intestinal lymphocytes. Europ. J. Immun. 17: 1279-1285, 1987. \n2.Parker, C. M., Cepek, K. L, Russell, G. J., Shaw, S. K., Posnett, D. N., Schwarting, R., Brenner, M. B. A family of beta-7 integrins on human mucosal lymphocytes. Proc. Nat. Acad. Sci. 89: 1924-1928, 1992. 3. Kilshaw PJ, Higgins JM (2002). \"Alpha E: no more rejection?\".\n

Additional Info

Recognizes human, mouse and rat ITGAE. No crossreactivity with other proteins.