JAK1, CT (Tyrosine-protein kinase JAK1, Janus kinase 1, JAK-1, JAK1A) (Biotin)

Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.\n\nApplications:\nSuitable for use in Immunohistochemistry, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nIHC1:100-500\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

037175-Biotin

Size

200ul

Applications

ELISA, IHC

Hosts

Rabbit

Reactivities

Hum, Mouse

Conjugates

Biotin

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to Biotin.

P Type

Pab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG

References

Yokota, S., et al., Virology 306(1):135-146 (2003).\nUsacheva, A., et al., J. Biol. Chem. 277(50):48220-48226 (2002).\nRadtke, S., et al., J. Biol. Chem. 277(13):11297-11305 (2002).\nMuller, M., et al., Nature 366(6451):129-135 (1993).\nHoward, O.M., et al., Oncogene 7(5):895-900 (1992).

Additional Info

Human, mouse

Alternative Names

Tyrosine-protein kinase JAK1, Janus kinase 1, JAK-1, JAK1A