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JAK1 (I1016) Peptide

JAK1 (I1016) Peptide

Cat no: BS1193P

Supplier: Bioworld Technology, Inc.
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JAK1 (Janus kinase 1) belongs to the family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation of catalytic events.
Catalogue number: BS1193P
Applications: Block/Neutralize/Inhibit
Swiss prot: P23458
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide JAK1 (I1016). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: Tyrosine-protein kinase JAK1; Janus kinase 1; JAK-1; JAK1A
Additional info: This peptide can be used with studies using BS1193 JAK1 (I1016) pAb.

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