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JAK1 (Tyrosine-protein Kinase JAK1, Janus Kinase 1, JAK-1, JAK1A, JAK1B)

Cat no: J0900-05H

JAK1 (Tyrosine-protein Kinase JAK1, Janus Kinase 1, JAK-1, JAK1A, JAK1B)

JAK1 is a member of the JAK (Janus kinase) family of protein tyrosine kinases including 4 family members JAK1, JAK2, JAK3, and TYK2 and which gets activated in response to a wide variety of polypeptide ligands. The protein has a C-terminal protein tyrosine kinase domain, an adjacent kinase-related domain and five further domains with aa similarity between members of the family extending towards the Nterminus. JAK1 plays important role in mediating signal transduction by the type I interferon receptor. JAK1 mutation functions as disease-modifying mutations in acute myeloid leukemia (AML) pathogenesis. Human JAK1 gene is mapped to chromosomal region 1p32.3-p31.3.\n\nApplications:\nSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 1:500-1:1000\nImmunohistochemistry (paraffin): 1:50-1:100\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nMCF7 cells\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

J0900-05H

Size

100ug

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Dmitry, G. et al. The EMBO Journal. 14:1421-1429 (1995).

Additional Info

Recognizes human JAK1. Species Crossreactivity: mouse and rat.

Read more on Supplier website

Applications

ELISA

Reactivities

Hum

More info

Applications

IF

Hosts

Mouse

More info

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, IHC, WB

Hosts

Mouse

More info

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

More info

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

More info
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