JIP-1 (A99) Peptide

Two additional JNK family members have been identified as JNK2 and JNK3. JIP-1 (for JNK interacting protein-1) has been identified as a cytoplasmic inhibitor of JNK that retains JNK in the cytoplasm, thereby inhibiting JNK-regulated gene expression. Evidence suggests that JNK1 and JNK2 bind to JIP-1 with greater affinity than to ATF-2 and c-Jun, which are targets of the JNK signaling pathway. JIP-1 contains an amino terminal JNK binding domain and a carboxy terminal SH3 domain. ATF-2 and c-Jun also contain the JNK binding domain and are thought to compete with JIP-1 for JNK binding. Multiple splice variants of JIP-1, including JIP-1b, JIP-1c (also designated islet-brain 1 or IB-1), JIP-2a, JIP-2b and JIP-3, have been identified in brain.

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SPECIFICATIONS

Catalog Number

BS9237P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide JIP-1 (A99). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

Q9UQF2

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS9237 JIP-1 (A99) pAb.

Alternative Names

C jun amino terminal kinase interacting protein 1; IB 1; IB1; Islet brain 1; JIP 1; JNK interacting protein 1; JNK MAP kinase scaffold protein 1; MAPK8IP 1; MAPK8IP1; MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1; Mitogen activated protein kinase 8 interacting protein 1; PRKM8; PRKM8 interacting protein; PRKM8IP