JIP-2 (N601) Peptide

Cat no: BS2046P

Supplier: Bioworld Technology, Inc.

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Description
Additional Information

c-Jun NH2-terminal kinases (JNKs) are distant members of the MAP kinase family. JNK1 is activated by dual phosphorylation at a Thr-Pro-Tyr motif in response to ultraviolet (UV) light, and it functions to phosphorylate c-Jun at amino terminal serine regulatory sites, Ser 63 and Ser 73, resulting in transcriptional activation. Two additional JNK family members have been identified as JNK2 and JNK3. JIP-1 (for JNK interacting protein-1) has been identified as a cytoplasmic inhibitor of JNK that retains JNK in the cytoplasm, thereby inhibiting JNK-regulated gene expression. Evidence suggests that JNK1 and JNK2 bind to JIP-1 with greater affinity than to ATF-2 and c-Jun, which are targets of the JNK signaling pathway. JIP-1 contains an amino terminal JNK binding domain and a carboxy terminal SH3 domain. ATF-2 and c-Jun also contain the JNK binding domain and are thought to compete with JIP-1 for JNK binding. Multiple splice variants of JIP-1, including JIP-1b, JIP-1c (also designated islet-brain 1 or IB-1), JIP-2a, JIP-2b and JIP-3, have been identified in brain.

Catalogue number:	BS2046P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	Q13387
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide JIP-2 (N601). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	MAPK8IP1; IB-1; IB1; JIP-1; JIP1; PRKM8IP
Additional info:	This peptide can be used with studies using BS2046 JIP-2 (N601) pAb.

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JIP-2 (N601) Peptide

Cat no: BS2046P

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