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KAL1 pAb

KAL1 pAb

Cat no: BS5771

Supplier: Bioworld Technology, Inc.
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Kallmann (KAL1) syndrome is an X-linked condition characterized by hypogonadism due to gonadotropin-releasing hormone (GnRH) deficiency, and a defective sense of smell, known as anosmia, due to the underdevelopment of the olfactory bulbs. GnRH is a key regulator of reproduction and sexual behavior. Anosmia associated with Kallmann syndrome is due to a defect in the migration and targeting of GnRH-secreting neurons and olfactory axons during embryonic development. Mutations in the KAL1 gene are responsible for X-linked Kallmann syndrome. The human KAL1 gene, located in the Xp22.3 region, encodes a 680 amino acid extracellular matrix adhesion protein, known as anosmin-1. Anosmin-1 plays an essential role in the patterning of mitral and tufted cell axon collaterals to the olfactory cortex. Anosmin-1 can be detected in the basement membranes and/or interstitial matrices of various structures including bronchial tubes, muscular walls of the digestive tract and forebrain subregions.
Catalogue number: BS5771
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug/100ul
Swiss prot: P23352
Dilutions: WB: 1:500~1:1000
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 205-250 of Human KAL1.
Species: KAL1 pAb detects endogenous levels of KAL1 protein.
Molecular weight: ~ 76 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Anosmin1; Anosmin-1; Adhesion molecule-like X-linked; Kallmann syndrome protein; KAL1; ADMLX; KAL; KALIG1
Additional info: For research use only, not for use in diagnostic procedure.

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