KAL1 Peptide

Cat no: BS5771P

Supplier: Bioworld Technology, Inc.

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Kallmann (KAL1) syndrome is an X-linked condition characterized by hypogonadism due to gonadotropin-releasing hormone (GnRH) deficiency, and a defective sense of smell, known as anosmia, due to the underdevelopment of the olfactory bulbs. GnRH is a key regulator of reproduction and sexual behavior. Anosmia associated with Kallmann syndrome is due to a defect in the migration and targeting of GnRH-secreting neurons and olfactory axons during embryonic development. Mutations in the KAL1 gene are responsible for X-linked Kallmann syndrome. The human KAL1 gene, located in the Xp22.3 region, encodes a 680 amino acid extracellular matrix adhesion protein, known as anosmin-1. Anosmin-1 plays an essential role in the patterning of mitral and tufted cell axon collaterals to the olfactory cortex. Anosmin-1 can be detected in the basement membranes and/or interstitial matrices of various structures including bronchial tubes, muscular walls of the digestive tract and forebrain subregions.

Catalogue number:	BS5771P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	P23352
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide KAL1. (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	Anosmin1; Anosmin-1; Adhesion molecule-like X-linked; Kallmann syndrome protein; KAL1; ADMLX; KAL; KALIG1
Additional info:	This peptide can be used with studies using BS5771 KAL1 pAb.

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KAL1 Peptide

Cat no: BS5771P

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