KDEL Receptor 2 (L119) Peptide

Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product.

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SPECIFICATIONS

Catalog Number

BS3123P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide KDEL Receptor 2 (L119). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

P33947

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS3123 KDEL Receptor 2 (L119) pAb.

Alternative Names

ER lumen protein retaining receptor 2; ERD2-like protein 1; ELP-1; ELP1; KDEL endoplasmic reticulum protein retention receptor 2; KDEL receptor 2; KDELR2; ERD2.2