KIF4A pAb

The kinesin superfamily proteins (KIFs) are microtubule-dependent molecular motors that transport membranous organelles and protein complexes in a microtubule- and ATP-dependent manner. Cells use KIFs to tightly control the direction, destination and speed of transportation of a variety of important functional molecules, including mRNA. KIF4A functions as an essential chromosome-associated molecular motor involved in faithful chromosome segregation. It is found in the nucleoplasm during interphase and on condensed chromosome arms during mitosis. KIF4A accumulates in the mid-zone duing late anaphase and on the cytokinetic ring during cytokinesis. KIF4 binds to and translocates PRC1, a spindle mid-zone-associated cyclin-dependent kinase that plays a role in cytokinesis. KIF4A may also interact with the condensin I and II complexes. Loss of KIF4A leads to chromosome hypercondensation, suggesting that it is necessary for retaining normal chromosome architecture.

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SPECIFICATIONS

Catalog Number

BS5774

Size

100ug/100ul

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to amino acids 1187-1232 of Human KIF4A.

Species

KIF4A pAb detects endogenous levels of KIF4A protein.

Dilutions

WB: 1:500~1:1000\nICC: 1:50~1:200

Swiss Prot

O95239

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul