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KIF4A pAb

KIF4A pAb

Cat no: BS5774

Supplier: Bioworld Technology, Inc.
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The kinesin superfamily proteins (KIFs) are microtubule-dependent molecular motors that transport membranous organelles and protein complexes in a microtubule- and ATP-dependent manner. Cells use KIFs to tightly control the direction, destination and speed of transportation of a variety of important functional molecules, including mRNA. KIF4A functions as an essential chromosome-associated molecular motor involved in faithful chromosome segregation. It is found in the nucleoplasm during interphase and on condensed chromosome arms during mitosis. KIF4A accumulates in the mid-zone duing late anaphase and on the cytokinetic ring during cytokinesis. KIF4 binds to and translocates PRC1, a spindle mid-zone-associated cyclin-dependent kinase that plays a role in cytokinesis. KIF4A may also interact with the condensin I and II complexes. Loss of KIF4A leads to chromosome hypercondensation, suggesting that it is necessary for retaining normal chromosome architecture.
Catalogue number: BS5774
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Western Blot
Size: 100ug/100ul
Swiss prot: O95239
Dilutions: WB: 1:500~1:1000 ICC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 1187-1232 of Human KIF4A.
Species: KIF4A pAb detects endogenous levels of KIF4A protein.
Molecular weight: ~ 140 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Chromosome-associated kinesin KIF4A; Chromokinesin-A; ChromokinesinA; Chromokinesin A; KIF4
Additional info: For research use only, not for use in diagnostic procedure.

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