KLRD1 pAb

The activity of natural killer (NK) cells is regulated by members of multiple receptor families that recognize class I MHC molecules, such as the killer cell inhibitory receptor/leukocyte immunoglobulin-like receptor (KIR/LIR) family and the C-type lectin superfamily (1,2). The KIR/LIR family includes p91A (also designated pp130 or PIR-B, for paired Immuno-globulin-like receptor-B) and p91B (also designated PIR-A). p91A acts as an inhibitory receptor through interactions with SHP-1, whereas p91B acts as an activating receptor (3-4). CD94, NKG2 and Ly-49 are members of the C-type lectin superfamily of type II membrane glycoproteins (5-7). CD94 forms heterodimers with NKG2 isoforms on the surface of NK cells, whereas Ly-49 isoforms form homodimers (5,6). NKG2-D, expressed on NK cells, gdT cells, and CD8+ (alpha)(beta) T cells, is a receptor for the stress inducible protein MICA, an antigen frequently expressed in epithelial tumors (8).

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SPECIFICATIONS

Catalog Number

BS6645

Size

100ug/100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Recombinant full length Human KLRD1.

Species

KLRD1 pAb detects endogenous levels of KLRD1 protein.

Dilutions

WB: 1:500~1:2000\nIHC: 1:50~1:200

Swiss Prot

Q13241

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 21 kDa

Alternative Names

CD 94; CD94; CD94 antigen; Killer cell lectin like receptor subfamily D member 1; Killer cell lectin-like receptor subfamily D member 1; KLRD 1; KLRD1; KLRD1 protein; KLRD1; KP 43; KP43; Natural killer cells antigen CD94; NK cell receptor;