KPNA1 pAb

Cat no: BS6647

Supplier: Bioworld Technology, Inc.

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Protein transport across the nucleus is a selective, multi-step process involving several cytoplasmic factors. Proteins must be recognized as import substrates, dock at the nuclear pore complex and translocate across the nuclear envelope in an ATP-dependent fashion. Two cytosolic factors centrally involved in the recognition and docking process are the karyopherin a1 and karyopherin (beta)1 subunits. Karyopherin a1 functions in the recognition and targeting of substrates destined for nuclear import, while karyopherin (beta)1 serves as an adapter, tethering the karyopherin (alpha)1/substrate complex to docking proteins on the nuclear envelope termed nucleoporins. Karyopherin a2 has been shown to complex with Epstein-Barr virus nuclear antigen 1 (EBNA1). Certain RNA-binding proteins are imported to the nucleus by karyopherin (beta)2, and karyopherin (beta)3 appears to be involved in the import of some ribosomal proteins.

Catalogue number:	BS6647
Reactivities:	Human, Mouse, Rat
Hosts:	Rabbit
Applications:	Immunohistochemistry, Western Blot
Size:	100ug/100ul
Swiss prot:	P52294
Dilutions:	WB: 1:500~1:2000 IHC: 1:50~1:200
Form:	liquid
Storage buffer:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration:	1ug/ul
Antigen:	Recombinant full length Human KPNA1.
Species:	KPNA1 pAb detects endogenous levels of KPNA1 protein.
Molecular weight:	~ 60 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp:	Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names:	IRCH2; SRP1; IPOA5; NPI-1;
Additional info:	For research use only, not for use in diagnostic procedure.

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KPNA1 pAb

Cat no: BS6647

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