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Kv3.3 (KCNC3, Voltage-gated Potassium Channel, KSHIIID, Potassium Voltage-gated Channel Subfamily C Member 3, Spinocerebellar ataxia 13, SCA13, Shaw-related Subfamily Member 3)

Cat no: K9011-50A

Kv3.3 (KCNC3, Voltage-gated Potassium Channel, KSHIIID, Potassium Voltage-gated Channel Subfamily C Member 3, Spinocerebellar ataxia 13, SCA13, Shaw-related Subfamily Member 3)

Kv3.3 is a member of the Shaw type family of voltage-gated K +channels that includes four members (Kv3.1-3.4). Kv3 subfamily members inactivate very rapidly and therefore are thought to play a role in the repolarization of action potentials and to facilitate repetitive high frequency firing. Kv3.3 is mostly localized in the brain, although it has been observed in vascular smooth muscle cells and eye epithelium. In the brain its expression pattern largely overlaps that of the Kv3.1 channel suggesting that they may form functional heteromers. Indeed, mouse knockouts of both Kv3.1 and Kv3.3, but not either channel alone, display severe motor defects. \n\nApplications: \nWestern Blotting: Rat brain membrane (1:200). \nImmunohistochemistry: Rat brain sections. Staining of Kv3.3 using Anti-Kv3.3. Immunoreactive neurons in the reticular thalamic nucleus detected with diaminobenzidine.

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SPECIFICATIONS

Catalog Number

K9011-50A

Size

50ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid in PBS, pH 7.2.

P Type

Pab

Purity

Purified

Isotype

IgG

References

1. Rudy, B. et al. (2001) Trends Neurosci. 24, 517.

Additional Info

Recognizes only splice variant Kv3.3

Read more on Supplier website

SUPPLIER INFO

United States Biological

Applications

ELISA

Reactivities

Hum

More info

Applications

IF

Hosts

Mouse

More info

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, IHC, WB

Hosts

Mouse

More info

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

More info

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

More info
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