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Lamin B1 mAb

Lamin B1 mAb

Cat no: MB2029

Supplier: Bioworld Technology, Inc.
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An important part of the nucleus is formed by nuclear lamina. Nuclear lamins form a network of filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A type lamins and B type lamins. The A type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. The nuclear lamins comprise a unique subclass of the intermediate filament protein family. They share a molecular domain organisation with the other intermediate filament proteins in that they are fibrous molecules that have an aminoterminal globular head, a central rod of alpha helices and a carboxy terminal globular domain. Many biochemical and molecular features of lamins have been studied, but their functions remain still largely undetermined. One of the functions ascribed to the lamina is the maintenance of the structural integrity of the nucleus.
Catalogue number: MB2029
Reactivities: Human, Mouse, Rat
Hosts: Mouse
Applications: Western Blot
Size: 100ug/100ul
Swiss prot: P20700
Dilutions: WB: 1:1000~1:5000
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Recombinant full length Human Lamin B1.
Species: Lamin B1 mAb detects endogenous levels of Lamin B1 protein.
Molecular weight: ~ 68 kDa
Purity: The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: LMNB1; LAMIN-B1; LMN; LMN2; LMNB; MGC111419
Additional info: For research use only, not for use in diagnostic procedure.

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