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LAT (D156) Peptide

Cat no: BS3757P

LAT (D156) Peptide

LAT, a transmembrane adaptor protein expressed in T, NK and mast cells, is an important mediator for T cell receptor (TCR) signaling. Upon TCR engagement, activated Zap-70 phosphorylates LAT at multiple conserved tyrosine residues within SH2 binding motifs, exposing these motifs as the docking sites for downstream signaling targets. The phosphorylation of LAT at Tyr171 and 191 enables the binding of Grb2, Gads/SLP-76, PLCgamma1 and PI3 kinase through their SH2 domain and translocates them to the membrane. This process eventually leads to activation of the corresponding signaling pathways.

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SPECIFICATIONS

Catalog Number

BS3757P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide LAT (D156). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

O43561

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS3757 LAT (D156) pAb.

Alternative Names

Linker for activation of T-cells family member 1; 36 kDa phospho-tyrosine adapter protein; pp36; p36-38; LAT

SUPPLIER INFO

Bioworld Technology, Inc.

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