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LAT (D199) Peptide

LAT (D199) Peptide

Cat no: BS1546P

Supplier: Bioworld Technology, Inc.
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LAT, a transmembrane adaptor protein expressed in T, NK and mast cells, is an important mediator for T cell receptor (TCR) signaling. Upon TCR engagement, activated Zap-70 phosphorylates LAT at multiple conserved tyrosine residues within SH2 binding motifs, exposing these motifs as the docking sites for downstream signaling targets. The phosphorylation of LAT at Tyr171 and 191 enables the binding of Grb2, Gads/SLP-76, PLCgamma1 and PI3 kinase through their SH2 domain and translocates them to the membrane. This process eventually leads to activation of the corresponding signaling pathways.
Catalogue number: BS1546P
Applications: Block/Neutralize/Inhibit
Swiss prot: O43561
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide LAT (D199). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: Linker for activation of T-cells family member 1; 36 kDa phospho-tyrosine adapter protein; pp36; p36-38; LAT
Additional info: This peptide can be used with studies using BS1546 LAT (D199) pAb.

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