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LKB1 (R425) Peptide

Cat no: BS1785P

LKB1 (R425) Peptide

LKB1, a member of the serine/threonine kinase family, is a tumor suppressor. Physically associates with p53, it regulates specific p53 dependent apoptosis pathways. LKB1 protein is present in both the cytoplasm and nucleus of living cells and translocates to mitochondria during apoptosis. Restoring LKB1 activity into cancer cell lines defective for its expression results in a G1 cell cycle arrest.Mutations in LKB1 gene are associated with Peutz Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. LKB1 functions as a master upstream protein kinase, regulating AMPK related kinases as well as AMPK.

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SPECIFICATIONS

Catalog Number

BS1785P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide LKB1 (R425). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

Q15831

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS1785 LKB1 (R425) pAb.

Alternative Names

Serine/threonine-protein kinase STK11; Liver kinase B1; LKB1; hLKB1; Renal carcinoma antigen NY-REN-19; STK11; LKB1; PJS

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