LRRK2 (Leucine-rich Repeat Kinase 2, Leucine-rich Repeat Serine/threonine Protein Kinase 2, AURA17, Dardarin, PARK8, RIPK7, ROCO2) (PE)

Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson's disease identified to date. LRRK2, a genetic mutation, was recently found linked to about 5 percent of inherited cases of Parkinson's disease. By high-resolution recombination mapping and candidate gene sequencing in 46 families, 6 disease-segregating mutations (5 missense and 1 putative splice site mutation). It may be central to the pathogenesis of several major neurodegenerative disorders associated with parkinsonism. LRRK2 belongs to the ROCO protein family and includes a protein kinase domain of the MAPKKK class and several other major functional domains.\n\nApplications: \nSuitable for use in ELISA, Western Blot, and Immunofluorescence. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-1:500\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze R-Phycoerythrin conjugates. Light sensitive. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

L4502-20J-PE

Size

200ul

Applications

ELISA, IF, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to R-Phycoerythrin (R-PE).

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1.Shen J. Neuron. 2004. 44:575. 2.Paisan-Ruiz C, et al. Neuron. 2004. 44(4):595. 3.Zimprich A, et al. Neuron. 2004. 44(4):601. 4.Wszolek ZK, et al. Neurology. 2004. 62(9):1619. 5.Park YJ, et al. Transplant Proc. 2004. 36(2):353. 6.Zimprich A, et al. Am J Hum Genet. 2004. 74:11. 7.Bonifati V. Lancet Neurol. 2002. 1:83. 8.Funayama M, et al.Ann Neurol. 2002. 51:296.

Additional Info

Recognizes human LRRK2.