LRRK2 (Leucine-rich Repeat Kinase 2, RIP7, PARK8, Dardarin)

Leucine-rich repeat kinase 2 (LRRK2) is a 2,527 amino acid protein encoded by the PARK8 gene and belonging to the ROCO family of proteins. This protein family is characterized as having a unique interaction between the Roc domain and the intrinsic GTPase activity along with a COR domain. LRKK2 consists of 5 different domains; a tyrosine kinase-like MAPKKK-related domain, WD40 propeller motif repeats, a Roc (Ras-like small GTPase family) domain, a COR (C-terminal of Roc) domain, and a LRRK. LRRK2 is mainly localized to the cytoplasm and expression within tissue is most highly observed within the brain. It is found in lower levels within the liver, heart, lung, skeletal muscles, placenta, pancreas, and kidney. The exact function of LRRK2 is unknown; however mutations to any of the five domains are the most commonly known causes of Parkinson

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SPECIFICATIONS

Catalog Number

L4502-21R

Size

100ug

Applications

IHC, WB

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in 0.1M Tris-Glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.

P Type

Mab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG1,k

References

1. Sancho, R., et al., Human Molecular Genetics 18(20): 3955-3968 (2009). 2. Khan, N., et al., Brain 128: 2786-2796 (2005). 3. Smith, W., et al., PNAS 102(51): 18,676-18,681 (2005). 4. Glasson, B., et al., Ann. Neurol. 59(2): 315-322 (2006).

Additional Info

Recognizes human LRRK2. A band is observed at 240kD (calculated MW is 286kD).