Ly49F (Klra6, Killer Cell Lectin-like Receptor, subfamily A, member 6, Killer Cell lectin-like receptor 6, Lymphocyte antigen 49f, T-cell surface glycoprotein Ly-49F)

The B6 allele of Ly49F is a member of the lectin-like homodimeric Ly49 family of cell surface receptors. Mouse Ly49 receptors exhibit allelic specificity for MHC class Ia molecules and are thought to serve to prevent natural killer (NK) cells from attacking normal cells, while allowing them to attack infected or transformed cells in which class I molecules have been down-regulated. These inhibitory receptors are also expressed on subpopulations of mouse CD8+ T cells. \n\nApplications:\nSuitable for use in Flow Cytometry. Other applications not tested.\n\nRecommended Dilutions:\nFlow Cytometry: (same/less than)1ug/10e6 cells\nOptimal dilutions to be determined by the researcher. \n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

L7732-25

Size

500ug

Applications

FC

Hosts

Mouse

Reactivities

Mouse

Form

Supplied as a liquid in 100mM borate buffered saline, pH 8.2.

P Type

Mab

Purity

Purified

Isotype

IgG1,k

References

1. Coles, M.C., C.W. McMahon, H. Takizawa, and D.H. Raulet. 2000. Eur. J. Immunol. 30:236. 2. Ljunggren, H.G., and K. Karre. 1990. Immunol. Today 11:237. 3. Coquet, J.M. et al., J. Immunol. 178: 2827.

Additional Info

Recognizes the B6 allele of the mouse Ly49F receptor. Stains ~11% of NK1.1+CD3- splenocytes, and 3.5% (2.5 month-old) to 10.0% (11 month-old) of CD8+ spleen cells from C57BL/6 mice.