Lymphotactin (LPTN, LTN, ATAC, C Motif Chemokine 1, Chemokine (C Motif) Ligand 1, Cytokine SCM-1, Lymphotaxin, SCM1, SCM-1, SCM-1-alpha, SCM-1a, Small-inducible Cytokine C1, SCYC1, XC Chemokine Ligand 1, XCL1)

Lymphotactin, otherwise known as XCL1, is the only member of the C-chemokine family identified so far. Unlike other members of the chemokine superfamily, Lymphotactin uniquely acts as a chemoattractant for lymphocytes, but not monocytes or neutrophils, suggesting an important regulatory role in lymphocyte trafficking and inflammation.\n\nLymphotactin, shown to signal through chemokine XC receptor 1 (XCR1), is detected at the highest level in the spleen and at low levels in the lungs, small intestine and colon, and is abundantly and selectively expressed by activated T cells, in particular CD8+ T cells, and is also produced by NK cells.\n\nApplications:\nSuitable for use in ELISA, Functional Assays, and Western Blot. Other applications not tested. \n\nRecommended Dilution:\nELISA: 0.5ug/ml\nWestern Blot: 0.1-0.2ug/ml\nFunctional Assays: 1.7-3ug/ml\nOptimal dilutions to be determined by the researcher. \n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile ddH2O or PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

L8010-03A

Size

100ug

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a lyophilized powder from PBS, pH 7.4. No preservative added. Reconstitute with 100ul sterile ddH2O.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Kennedy, J. et al. (1995) Molecular cloning and functional characterization of human Lymphotactin. J. Immunol. 155: 203-209.\n2. Hedrick, J.A. et al. (1997) Lymphotactin is produced by NK cells and attracts both NK cells and T cells in vivo. J. Immunol. 158: 1533-1540.

Additional Info

Recognizes human lymphotactin.