Lymphotoxin beta Receptor (LTBR, LT-beta-R, Tumor Necrosis Factor C Receptor, Tumor Necrosis Factor Receptor Superfamily Member 3)

The monoclonal antibody to mouse LTBR is an agonist that can be used for the investigation of the regulation of BAFF(BlyS), chemokines and integrins using in vivo and tissue culture models, the development of NK cells, and NK T cells, to study the regulation of NF-kB family of transcription factors in regulation of inflammation and homeostasis, particularly RelB NF-kB2 pathway. For use as an agonist the MAb to LTBR is added to cell cultures at 2ug/ml. For in vivo use, mice are injected intraperitoneally with 50ug of agonistic MAb to LTBR in sterile phosphate saline.\n\nApplications: \nSuitable for use in Flow Cytometry and Functional Application (agonist inducing BAFF, chemokines and integrins in vitro and in vivo). Other applications have not been tested. \n\nRecommened Dilution: \nOptimal dilutions to be determined by researcher. \n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. \n\n \n\n\n\n

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SPECIFICATIONS

Catalog Number

L8015-02

Size

100ug

Applications

FC

Hosts

Rat

Reactivities

Mouse

Form

Supplied as a liquid in PBS, pH 7.4.

P Type

Mab

Purity

98% (SDS-PAGE).

Isotype

IgG2a

References

1. E. Dejardin, et al. (2002) Immunity 17:525. 2. B. Silva-Santos, et al. (2005) Science 307:925. 3. W.R. Force, et al. (1995) J. Immunol. 155:5280. \n\n

Additional Info

Recognizes mouse LTBR.