Lysosome Associated Membrane Protein 1 (LAMP 1, CD107a, Igp120, IgpA)

CD107a, also known as Lysosome-Associated Membrane Protein 1 (LAMP-1) or LGP-120, is a 110-140kD type I membrane glycoprotein. The mature CD107a is heavily glycosylated from a 40kD core protein. It is expressed by macrophages, epithelial cells, endothelial cells, and some tumor cells. This molecule is located on the luminal side of lysosomes and has been suggested to play a role in the protection of the lysosome membrane from lysosomal hydrolases. CD107a is a ligand for galaptin. Upon activation, CD107a is transferred to the surface of the cell membrane. It plays a role in cell adhesion and regulation of tumor metastasis and mediates autoimmune disease progression.\n\nApplications:\nSuitable for use in Flow Cytometry, Immunohistochemistry, Immunofluorescence and Immunoprecipitation. Other applications not tested.\n\nRecommended Dilution:\nFlow Cytometry: (same/less than)0.25ug/10e6 cells in 100ul volume\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

L9190-08C

Size

50ug

Applications

FC, IF, IHC, IP

Hosts

Rat

Reactivities

Mouse

Form

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

P Type

Mab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG2a,k

References

1. Barclay AN, et al. 1997. The Leucocyte Antigen Facts Book. 2nd Edition. Academic Press. 2. Heffernan M, et al. 1989. Cancer Res. 49:6077. 3. Granger BL, et al. 1990. J. Bio. Chem. 265:12036. 4. De Carvalho Bittencourt M, et al. 2005. Eur. J. Immunol. 35:1501.

Additional Info

Recognizes mouse CD107a.