Lysyl Oxidase (LOX, Protein-lysine 6-oxidase)

Protein-lysine-6 oxidase; LOX (EC 1.4.3.13), a 30kD copper-containing amine oxidase, belongs to a heterogeneous family of enzymes that oxidize primary amine substrates to reactive aldehydes. It plays a vital role in the formation and repair of ECM. Localized both in the cytosol and nucleus, it catalyzes the oxidation and deamination of epsilon-NH2 group of lysine and hydroxylysine residues to alpha-aminoadipic-delta-semialdehyde. This is the first step that initiates the covalent cross-linking of collagen and tropoelastin resulting in the formation of insoluble collagen and elastic fibers in the extracellular matrix. LOX is a multifunctional enzyme having diverse biological functions such as developmental regulation, tumor suppression, cell motility and cellular senescence. Deficiency of LOX is seen in certain carcinomas and 3X-linked recessive human connective tissue disorders

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

L2623-11A

Size

100ul

Applications

IF, IHC, IP, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid, 0.025% sodium azide, 50% glycerol.

P Type

Pab

Purity

Serum

Isotype

IgG

References

1. Mariani, T.J., Trackman, P.C., Kagan, H.M., et al., Matrix 12(3), 242-248 (1992). 2. Kaneda, A., Wakazono, K., Tsukamoto, T., et al., Cancer Res. 64 (18), 6410-6415 (2004). 3. Hong, H.H., Pischon, N., Santana, R.B., et al., J. Cell. Physiol. 200(1), 53-62 (2004). 4. Fogelgren, B., Polgar, N., Szauter, K.M., et al., J. Biol. Chem. 280(26), 24690-24697 (2005).

Additional Info

Recognizes human LOX.