LZK (F183) pAb

Cat no: BS1874

Supplier: Bioworld Technology, Inc.

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Description
Additional Information

Mixed lineage kinases (MLKs) are a family of protein kinases sharing two leucine zipper-like motifs which mediate protein dimerization, and a kinase domain with a similar primary structure to both the tyrosine-specific and the serine/threonine-specific kinase classes. Members of the MLK family include MLK1, MLK2, MLK3, MLK4, MELK, LZK and DLK. MLKs are expressed in neuronal cells where they are likely to interact between Rac1/Cdc42, MKK4 and MKK7 in death signaling. Leucine zipper-bearing kinase (LZK) also activates the c-Jun-NH2 terminal kinase/stress-activated protein kinase (JNK/ SAPK) pathway though MKK7. Through its dual leucine zipper-like motif, LZK forms dimers/oligomers which are important for activation of the JNK/SAPK pathway. LZK is predominantly expressed in the pancreas, while moderate expression is observed in adult brain, liver and placenta tissues.

Catalogue number:	BS1874
Reactivities:	Human, Mouse, Rat
Hosts:	Rabbit
Applications:	Immunohistochemistry, Western Blot
Size:	100ug/100ul
Swiss prot:	O43283
Dilutions:	WB: 1:500~1:1000 IHC: 1:50~1:200
Form:	liquid
Storage buffer:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration:	1ug/ul
Antigen:	Synthetic peptide, corresponding to amino acids 161-210 of Human LZK.
Species:	LZK (F183) pAb detects endogenous levels of LZK protein.
Molecular weight:	~108 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp:	Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names:	LZK; M3K13; MAP3K13; MEKK13; MGC133196; Mitogen activated protein kinase kinase kinase 13; Mitogen-activated protein kinase kinase kinase 13; Mixed lineage kinase; MLK; OTTHUMP00000210397;
Additional info:	For research use only, not for use in diagnostic procedure.

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LZK (F183) pAb

Cat no: BS1874

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