Macrophage Colony Stimulating Factor (M-CSF, MCSF, Colony Stimulating Factor 1, CSF1, Lanimostim, Macrophage Colony Stimulating Factor 1, MGC31930)

Colony stimulating factor-1 (M-CSF) is a glycoprotein growth factor required for the proliferation and differentiation of mononuclear phagocytic cells. Findings indicate that M-CSF, under hormonal influence, plays a role in placental development and function and that steroid hormones may regulate developmental processes via their effects on the expression of tissue-specific growth factors (1). M-CSF accelerates neointimal formation after vascular injury via the SDF-1-CXCR4 system, and the inhibition of this system has therapeutic potential for the treatment of cardiovascular diseases (2). The immunosuppressor Sanglifehrin A inhibits M-CSF-dependent macrophage proliferation by arresting the G1 phase of the cell cycle but does not affect cell viability (3). Several studies have demonstrated that CSFs are closely associated with tumor progression, metastasis and invasion through autocrine or paracrine mechanism in lung cancer (4).\n\nApplications:\nSuitable for use in Western Blot, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 1:50,000 (5ng recombinant protein) \nImmunoprecipitation: 1:50\nImmunohistochemistry: 1:50

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SPECIFICATIONS

Catalog Number

M1201-04H

Size

100ul

Applications

ICC, IHC, IP, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in 50mM Tris-Glycine, pH 7.4, 0.15M sodium chloride, 40% Glycerol, 0.01% sodium azide, 0.05% BSA.

P Type

Mab

Purity

Supernatant

Isotype

IgG

References

1. Pollard JW, et al. Nature 330(6147):484-6, 1987. 2. Shiba Y, et al. Arterioscler Throm Vasc Biol, 27(2):283-9,006 3. Sanchez-Tillo E, et al. Eur J Immunol. 36(9):2515-24, 2006 4. Uemura Y, et al. Int J Mol Med 18(2):365-73, 2006.

Additional Info

Recognizes human M-CSF.