MALT1 (Paracaspase, Mucosa-associated Lymphoid Tissue Lymphoma Translocation Protein 1)

MALT1/Paracaspase (MALT1) was independently identified as a member of the human paracaspase family and an interacting partner of B-cell lymphoma (Uren et al., 2000). MALT1 is a caspase-like protein that contains an N-terminal death domain, two Ig-like domains, and a C-terminal caspase-like domain. It binds to Bcl-10 through its Ig-like domains and cooperates with Bcl-10 to activate NF-kappaB. MALT1 is thought to play an important role in NF-kappaB signaling by enchancing NF-kappaB activation through interaction with Bcl-10 (Ho et al., 2005). Interaction between MALT1 and Bcl-10 mediates IKK activation in vitro through facilitatiing the ubiquitination of NEMO by the ubiquitin-conjugating enzyme UBC13.\n\nApplications: \nSuitable for use in Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nImmunohistochemistry(Paraffin): 1:200-1:400\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

138567

Size

20ug

Applications

IHC

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.

P Type

Pab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG1,k

References

1. Uren,A.G., O'Rourke,K., Aravind,L.A., Pisabarro,M.T., Seshagiri,S., Koonin,E.V. and Dixit,V.M. Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma Mol. Cell 6(4), 961-967 (2000). 2. Ho L, RE Davis, B Conne, R Chappuis, M Berczy, P Mhawech, LM Staudt, and J Schwaller. 2005. MALT1 and the AP12-MALT1 fusion act between CD40 and IKK and confer NF-kB dependent proliferative advantage and resistance against FAS-induced cell death in B cells. Bood 105:2891-2899. 3. PG Isaacson and M-Q Du. 2004. MALT lymphoma: from morphology to molecules. Nature Reviews/Cancer 4:644-653. 4. PG Isaacson. 2005. Update on MALT lymphomas. Best Practice & Research Clinical Haematology. 18:57-68. 5. Yonezumi M, R Suzuki, H Suzuki, T Yoshino, K Oshima, Y Hosokawa, M Asaka, Y Morishima, S Nakamura, and M Seto. 2001. Detection of AP12-MALT1 chimaeric gene in extranodal and nodal marginal zone B-cell lymphoma by reverse transcription polymerase chain reaction (PCR) and genomic long and accurate PCR analyses. Br J of Haematology. 115:588-594.

Additional Info

Recognizes human MALT1.