Mannose Binding Protein (Mannan Binding Protein (MBP, Mannan Binding Lectin, MBL) (FITC)

Mannose Binding Lectin (MBL) also called mannose- or mannan-binding protein (MBP) is a member of the group of collectins. MBL is an oligomeric lectin that recognizes carbohydrates as mannose and N-acetylglucosamine on pathogens. MBL contains a cysteine rich, a collagen like and a carbohydrate recognition domain. It forms a complex with C1r/C1s like serine proteases designated MASPs that proteolytically cleave C4, C2 and C3. MBL is able to activate the complement pathway independent of the classical and alternative complement activation pathways. The MBL-MASP pathway (better known as the lectin pathway) is antibody and C1q

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SPECIFICATIONS

Catalog Number

M2250-01D

Size

100ug

Applications

ELISA, FC, IHC, WB

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS, 1% BSA, 0.02% sodium azide. Labeled with Fluorescein isothiocyanate (FITC).

P Type

Mab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG1

References

1. Muto, S et al;Biochimica et Biophysica Acta 2001, 1527: 39 2. Matsushita, M et al; Biochem Biophys Res Commun 1992, 183: 645 3. Hisano, S et al; Am J Kidney Dis 2001, 38: 1082 4. Vries de, B et al; Am J Pathol 2004, 165: 1677 5. Nauta, A et al; Eur J Immunol 2003, 33 : 2853 6. Nauta, A et al ; J Immunol 2004, 173: 3044

Additional Info

Recognizes human Mannose Binding Lectin.

Alternative Names

mannose-binding lectin