MAP Kinase 1 (Mitogen-activated Protein Kinase 1, MAPK 1, MAPK1, ERT1, Extracellular Signal-regulated Kinase 2, ERK2, ERK-2, ERK, MAP Kinase Isoform p42, Mitogen-activated Protein Kinase 2, MAP Kinase 2, MAPK 2, MAPK2, p41mapk, p42-MAPK, P42MAPK, PRKM1, P

Mitogen-activated protein kinases (MAPKs) are reported to be critical regulatory factors for the growth andmigration of various cell types including vascular smooth muscle cells (VSMCs). It has also been reported that the activation of the MAP kinase family, extracellular signal regulated kinases 1/2 (ERK1/2), and c-Jun N-terminal kinase (JNK) via Src activation is important for AII-induced migration of VSMCs. MAPKs are intracellular signal-transduction pathways that have been shown to play a central role in the development of injury following ischemia in the brain and heart. MAPKs regulate gene expression, which is important in cell injury/repair and proliferation/differentiation.\n\nApplications:\nSuitable for use in ELISA, Immunofluorescence and Western Blot. Other applications not tested.\n\nRecommended Dilutions:\nELISA: 1:500\nWestern Blot: 1:500-1:3000\nImmunofluorescence: 1:500-1:3000\nOptimal dilutions to be determined by the researcher. \n\nHybridoma: \nFO myeloma cells with spleen cells from Balb/c mice. \n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

M2351-80J

Size

50ul

Applications

WB

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.

P Type

Mab

Purity

Purified

Isotype

IgG2b,k

References

1. Le A, et al. (2010) Proc Natl Acad Sci U S A, 107(5):2037-42. 2. Gesslein B, et al. (2010) Mol Vis,16:392-407. 3. Lai EW, et al. (2004) J Invest Surg, 17:45-53.\n

Additional Info

Recognizes human MAPK1.

Alternative Names

EC=2.7.11.24, p38, p40, p41