MAP2K4, phosphorylated (pS257) (EC 2.7.12.2, MAP kinase kinase 4, JNK-activating kinase 1, c-Jun N-terminal kinase kinase 1, JNKK, SAPK/ERK kinase 1, SEK1) (APC)

This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver.\n\nApplications:\nSuitable for use in Dot Blot, ELISA\n\nRecommended Dilution:\nELISA1:1,000 \nDot blot 1:500\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze APC conjugates. Light sensitive. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

038131-APC

Size

200ul

Applications

ELISA

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to Allophycocyanin (APC).

P Type

Pab

Purity

Purified by peptide immunoaffinity chromatography.

Isotype

IgG

References

Kasper,B., J. Immunol. 179 (4), 2584-2591 (2007) Zhang,H., J. Biol. Chem. 282 (20), 14788-14796 (2007) Korhonen,R., Mol. Pharmacol. 71 (5), 1427-1434 (2007) Xia,D., J. Biol. Chem. 282 (6), 3507-3519 (2007)

Additional Info

Human

Alternative Names

EC 2.7.12.2, MAP kinase kinase 4, JNK-activating kinase 1, c-Jun N-terminal kinase kinase 1, JNKK, SAPK/ERK kinase 1, SEK1