Matrix Metalloproteinase 15 (MMP-15, MMP15, Membrane Type 2 Matrix Metalloproteinase, MT2-MMP, MT2MMP, Membrane Type Matrix Metalloproteinase 2, MT-MMP-2, MTMMP2, SMCP-2)

MMPs are a group of enzymes involved in matrix degradation. Of the sixteen members of matrix metalloproteinase family ten exist in soluble form whereas MT MMPs exist as integral membrane proteins. MT1 MMp, MT2 MMP and MT3 MMP also known as MMP 14, MMP 15 and MMP 16 respectively. They contain a C-terminal transmembrane domain anchoring them to the cell surface. MT2 MMP plays a minor role in activation of pro-MMP 2 to its active form in breast carcinomas. Coexpression of MT1 MMP and MT2 MMP in advanced stages of breast carcinomas is indicative of possible involvement of MT2 MMP in its metastasis.\n\nCellular Localization: Cell Membrane\n\nPositive Control: Suitable tissue control sections for Immunohistochemistry:Placenta.\n\nApplications: \nSuitable for use in Immunofluorescence and Immunohistochemistry (Fr) (paraffin-embedded sections). Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

M2430-03B

Size

500ul

Applications

IF, IHC

Hosts

Rabbit

Reactivities

Hum

Form

Serum

P Type

Pab

Purity

Serum

Isotype

IgG

References

Takino T et al. Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library. MT-MMPs form a unique membrane-type subclass in the MMP family. J Biol Chem 270:23013-20 (1995). <PUBMED:7559440>Sato H et al. A matrix metalloproteinase expressed on the surface of invasive tumour cells. Nature 370:61-5 (1994). <PUBMED:8015608>

Additional Info

Species Crossreactivity: Crossreacts with Human.

Alternative Names

Matrix Metallopeptidase 15 (Membrane-inserted)