MBP (MBP, Myelin basic protein, Myelin A1 protein, Myelin membrane encephalitogenic protein)

The protein encoded by the classic MBP gene is a major\r constituent of the myelin sheath of oligodendrocytes and Schwann\r cells in the nervous system. However, MBP-related transcripts are\r also present in the bone marrow and the immune system. These mRNAs\r arise from the long MBP gene (otherwise called 'Golli-MBP') that\r contains 3 additional exons located upstream of the classic MBP\r exons. Alternative splicing from the Golli and the MBP\r transcription start sites gives rise to 2 sets of MBP-related\r transcripts and gene products. The Golli mRNAs contain 3 exons\r unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They\r encode hybrid proteins that have N-terminal Golli aa sequence\r linked to MBP aa sequence. The second family of transcripts contain\r only MBP exons and produce the well characterized myelin basic\r proteins. This complex gene structure is conserved among species\r suggesting that the MBP transcription unit is an integral part of\r the Golli transcription unit and that this arrangement is important\r for the function and/or regulation of these genes. [provided by\r RefSeq].\n\nApplications:\nSuitable for use in Western Blot, Immunofluorescence, ELISA.\n\nRecommended Dilution: \nELISA: 1:1,000\nWestern Blot: 1:5000~16000\nImmunofluorescence: 1:10~50\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

031114

Size

100ul

Applications

ELISA, IF, WB

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid, crude ascites with 0.09% sodium azide.

P Type

Mab

Purity

Ascites

Isotype

IgM

References

Walsh, C.M., et al. Biochem. J. 430(3):453-460(2010)\r Han, S., et al. Hum. Immunol. 71(7):727-730(2010)\r Martins-de-Souza, D., et al. J Psychiatr Res (2010) In press\r Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010)\r Pan, H., et al. Sichuan Da Xue Xue Bao Yi Xue Ban 40(5):775-779(2009)

Additional Info

Human

Alternative Names

MBP, Myelin basic protein, Myelin A1 protein, Myelin membrane encephalitogenic protein