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MC4-R (E315) pAb

MC4-R (E315) pAb

Cat no: BS2811

Supplier: Bioworld Technology, Inc.
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MC4 receptor is the fourth member of the five known melanocortin receptors (MCRs) belonging to the rhodopsin-like family of G protein-coupled receptors (GPCRs). These five MCRs form a unique family of GPCRs, marked by their unusually short coding sequence and the absence of highly conserved amino acid residues or motifs common to most GPCRs. All MCRs signal through the cyclic adenosine 3', 5'-monophosphate (cAMP) pathway. With the exception of MC2R, all MCRs are activated by both adrenocorticotropin (ACTH) and melanocyte-stimulating hormones (MSHs and mainly alpha-MSH). The MC4R receptor is expressed primarily in the brain, and unlike the other melanocortin receptors, MC4R is not expressed in adrenal cortex or in melanocytes. Genetic studies of mice and humans have established a critical role of MC4 Receptor in appetite regulation. Heterozygous mutations in MC4 Receptor account for 1-6% of severe cases of human obesity.
Catalogue number: BS2811
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: P32245
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 300-350 of Human MC4-R.
Species: MC4-R (E315) pAb detects endogenous levels of MC4-R protein.
Molecular weight: ~ 37 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: MC4R; MC4-R; MGC126851; MGC138197
Additional info: For research use only, not for use in diagnostic procedure.

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