MC4-R (E315) Peptide

Cat no: BS2811P

Supplier: Bioworld Technology, Inc.

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MC4 receptor is the fourth member of the five known melanocortin receptors (MCRs) belonging to the rhodopsin-like family of G protein-coupled receptors (GPCRs). These five MCRs form a unique family of GPCRs, marked by their unusually short coding sequence and the absence of highly conserved amino acid residues or motifs common to most GPCRs. All MCRs signal through the cyclic adenosine 3', 5'-monophosphate (cAMP) pathway. With the exception of MC2R, all MCRs are activated by both adrenocorticotropin (ACTH) and melanocyte-stimulating hormones (MSHs and mainly alpha-MSH). The MC4R receptor is expressed primarily in the brain, and unlike the other melanocortin receptors, MC4R is not expressed in adrenal cortex or in melanocytes. Genetic studies of mice and humans have established a critical role of MC4 Receptor in appetite regulation. Heterozygous mutations in MC4 Receptor account for 1-6% of severe cases of human obesity.

Catalogue number:	BS2811P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	P32245
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide MC4-R (E315). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	MC4R; MC4-R; MGC126851; MGC138197
Additional info:	This peptide can be used with studies using BS2811 MC4-R (E315) pAb.

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MC4-R (E315) Peptide

Cat no: BS2811P

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