Mcl-1 (S121) Peptide

Cat no: BS1220P

Supplier: Bioworld Technology, Inc.

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B cell CLL/lymphoma-2 (Bcl-2) blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal. Myeloid cell leukemia-1 (Mcl-1) shares sequence homology with Bcl-2 and further resembles Bcl-2 in that its expression promotes cell viability. p53 and Mcl-1 demonstrate opposing effects on mitochondrial apoptosis by mediating Bcl-2 antagonist killer (Bak) activity. Mcl-1 is an important and specific regulator that is necessary for the homeostasis of early hematopoietic progenitors. Glycogen synthase kinase-3 (GSK-3) controls Mcl-1 stability, which has an effect on the regulation of apoptosis by growth factors PI 3-kinase and Akt. Mice with a deficiency of the Mcl-1 protein show a significant reduction in B and T lymphocytes similar to the effects observed in IL-7- or IL-7R-deficient mice.

Catalogue number:	BS1220P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	Q07820
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide Mcl-1 (S121). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	MCL1; EAT; MCL1/EAT; MCL1L; MCL1S; MGC104264; MGC1839; TM
Additional info:	This peptide can be used with studies using BS1220 Mcl-1 (S121) pAb.

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Mcl-1 (S121) Peptide

Cat no: BS1220P

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