MCM6 (p105MCM)

MCM6(Minichromosome maintenance, s. pombe, homolog of, 6) is a protein that in humans is encoded \nby the MCM6 gene. MCM6 is one of the highly conserved mini-chromosome maintenance proteins \n(MCM) that are essential for the initiation of eukaryotic genome replication. The MCM genes were \noriginally identified in yeast defective in minichromosome maintenance and have since been shown to \nplay roles in the progression of the cell cycle; many are cell division control genes. The MCM6 gene is \nmapped on 2q21.3. Mcm 6 has recently been shown to interact strongly Cdt1 at defined residues, by \nmutating these target residues Wei et al. observed lack of Cdt1 recruitment of Mcm2-7 to the pre-RC.\nAn approximately 200-kb region surrounding the C/T(-13910) polymorphism in MCM6 intron 13 \nfunctioned as an enhancer of the lactase gene promoter in intestinal cell culture.\n\nUniProt Number:\nQ14566\n\nGene ID:\nMCM6\n\nApplications:\nSuitable for use in Western Blot, Immunohistochemistry (Paraffin and Frozen), and Immunocytochemistry.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Handling:\nStore at -20?C for one year. After reconstitution, store at 4?C for one month. Can also be aliquoted and stored frozen at -20?C for long term.\nAvoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

144889

Size

100ug

Applications

ICC, IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a lyophilized powder. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Bersaglieri, T., Sabeti, P. C., Patterson, N., Vanderploeg, T., Schaffner, S. F., Drake, J. A., Rhodes, \nM., Reich, D. E., Hirschhorn, J. N. Genetic signatures of strong recent positive selection at the \nlactase gene. Am. J. Hum. Genet. 74: 1111-1120, 2004.\n2. Coelho, M., Luiselli, D., Bertorelle, G., Lopes, A. I., Seixas, S., Destro-Bisol, G., Rocha, \nJ. Microsatellite variation and evolution of human lactase persistence. Hum. Genet. 117: 329-339, \n2005.\n3. Enattah, N. S., Sahi, T., Savilahti, E., Terwilliger, J. D., Peltonen, L., Jarvela, I. Identification of a \nvariant associated with adult-type hypolactasia. Nature Genet. 30: 233-237, 2002.

Additional Info

Recognizes human, mouse and rat MCM6. No crossreactivity with other proteins.