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MDM2 (F414) Peptide

MDM2 (F414) Peptide

Cat no: BS1223P

Supplier: Bioworld Technology, Inc.
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p53 is the most commonly mutated gene in human cancer identified to date. Expression of p53 leads to inhibition of cell growth by preventing progression of cells from G1 to S phase of the cell cycle. Most importantly, p53 functions to cause arrest of cells in the G1 phase of the cell cycle following any exposure of cells to DNA-damaging agents. The MDM2 (murine double minute-2) protein was initially identified as an oncogene in a murine transformation system. MDM2 functions to bind p53 and block p53-mediated transactivation of cotransfected reporter constructs. The MDM2 gene is amplified in a high percentage of human sarcomas that retain wildtype p53 and tumor cells that overexpress MDM2 can tolerate high levels of p53 expression. These findings argue that MDM2 overexpression represents at least one mechanism by which p53 function can be abrogated during tumorigenesis.
Catalogue number: BS1223P
Applications: Block/Neutralize/Inhibit
Swiss prot: Q00987
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide MDM2 (F414). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: Double minute 2 protein; E3 ubiquitin-protein ligase Mdm2; Hdm 2; Hdm2; MDM 2; MDM2; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein 104 a; MDM2; MDM2BP; MDM2BP; Mouse Double Minute 2; Mouse Double Minute 2; MTBP; Murine Double Minute Chromosome 2; Oncoprotein Mdm2; p53 Binding Protein Mdm2; p53 Binding Protein Mdm2; p53-binding protein Mdm2; Ubiquitin protein ligase E3 Mdm2; Ubiquitin protein ligase E3 Mdm2;
Additional info: This peptide can be used with studies using BS1223 MDM2 (F414) pAb.

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